TPD did not correlate with headache days per month or the dominant headache side in migraine patients. There was a significant, moderate association with age for the right side ( r = 0.42 p = 0.002, n = 51), and less strong association for the left side ( r = 0.34, p = 0.14) in healthy individuals. Migraine patients had larger TPD thresholds (26.86 ± 7.21) than healthy controls (23.30 ± 6.17) but these became only statistically significant for the right side of the neck ( p = 0.02). The same protocol was applied by two further examiners to 28 migraine patients and 21 age-, and gender-matched healthy controls to investigate inter-rater reliability and between group differences. To introduce a standardized protocol for the measurement of TPD in the upper cervical spine, 51 healthy participants were investigated with a newly developed paradigm which was evaluated for intra-rater reliability. ![]() Limited evidence exists for tactile acuity in the neck and no data is available for migraine. ![]() Previous reports proposed two-point discrimination (TPD) as a measurement for cortical alterations. Chronic pain including migraine is associated with structural and functional changes in the somatosensory cortex.
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